Understanding robustness in circadian clocks through sampling and analysis of an ensemble of models consistent with experimental data

Faculty Mentors: Aaron Dinner (University of Chicago) & Michael Rust (University of Chicago)

Circadian clocks are essential biological oscillators that maintain stable 24-hour rhythms despite significant fluctuations in environmental conditions, such as temperature and nutrient availability. However, these systems must remain sensitive enough to be synchronized, or “entrained,” by the environment, creating a fundamental tension between stability and adaptability. This project investigates the cyanobacterial clock—a well-defined system that can be studied in a test tube—to identify the molecular mechanisms that allow for this balance. By analyzing an ensemble of mathematical models consistent with experimental data, the researchers aim to bridge the gap between specific protein interactions and the robust, reliable timekeeping behavior observed in living cells.