Chicago, IL 60611 United States
Overview
The vibrant, multidisciplinary field of mathematical morphogenesis develops the theoretical foundations for understanding biological growth and form. A key focus area this field concerns the study of collective cell behavior with the range of research spanning a broad spectrum, from the fundamentals, e.g., uncovering underlying molecular mechanisms, theoretical soft matter physics and the mathematics of many-particle systems, to applications in biology, e.g., developing multi-scale mathematical modeling of specific developmental processes, wound healing, cancer progression, and immune cells migration dynamics. Model systems such as Drosophila, Zebrafish, and mammalian organoids serve as some of primary experimental platforms for integrating mathematical modeling and experiments. Presenters at this workshop will discuss recent progress in mathematical multi-scale modeling of multicellular systems, translational modeling approaches that generate biologically testable predictions, and data-driven and machine learning methodologies used in model development and data analysis.
By bringing together researchers at different career stages, the meeting will foster the exchange of ideas, introduce innovative approaches, and promote new interdisciplinary collaborations and novel educational approaches. Interdisciplinary focus groups will address combinations of the following central questions: 1) What are the hallmarks of coherent-collective cell migration? 2) How do you evaluate competing mathematical models of collective cell behavior? 3) What is the best way to capture both chemical and mechanical dynamics in deforming and growing 3D cellular domains? 4) How do we calibrate and test models to establish verified digital twins of morphogenesis?