Internal Project Grants
Policies
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The submitting investigator must be an NITMB Faculty (this corresponds to the membership list https://www.nitmb.org/nitmb-faculty) and their collaborators at Northwestern University, the University of Chicago, or other universities. Funds for project personnel and supplies may only be distributed to Northwestern or the University of Chicago.
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Investigators and collaborators can be funded by at most two internal projects and serve as PI for at most one project total, across all funding rounds. Note that the NITMB mission is to increase engagement among diverse disciplines, so proposals to support investigators already funded by NITMB may receive lower priority.
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Funds can be used to support the stipend/salary/fringe/tuition/fees of graduate Research Assistants and salary/fringe of postdoctoral scholars. Funds cannot be used to support tenure-track faculty salaries, non-tenure track faculty salaries, research staff, or administrative staff.
Funding: Allowable Types of Research Positions
Role | Allowable Years | Restrictions | Mentoring Plan |
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Undergraduate Research Assistant | Years 01-05 | Required | |
Post-baccalaureate Research Assistant | The first 01-03 years post graduation | Limited teaching assistant work and coursework | Required |
Masters Student | Years 02-03 | Limited teaching assistant work and coursework | Required |
PhD Student/Candidate | Years 02-06 | Limited teaching assistant work and coursework | Required |
Postdoctoral Scholar | Years 01-05 of 1st Postdoc | 1st Postdoc position | Required |
Postdoctoral Scholar | Years 01-05 of 2nd Postdoc | 2nd Postdoc position in a new field, with intention to apply for faculty positions | Required |
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Funds cannot be used to purchase capital equipment. No more than $10,000 (direct costs) may be spent on experimental supplies and services. Funds cannot be used to purchase computer equipment or purchase/lease software.
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The term of funding is 12 months. There is a competitive renewal process by which awardees may request another 12 months and commensurate funding. Renewal will depend on the Merit Review Criteria evaluated above as well as progress made towards project goals, and the engagement of the project’s investigators in NITMB activities (education, outreach, convenings, etc.).
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Responsible Conduct of Research (RCR) training is required for all personnel funded on this award to be completed within the first 6 months of the award. RCR training completed within the last four years counts toward this requirement, but must not expire during the funding period. This includes faculty, senior personnel, undergraduate students, graduate research assistants, and postdoctoral researchers.
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At the end of the funding period (i.e., at the end of the initial 12-month period or at the end of any renewal period):
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A final written progress report is required from the investigators, documenting research progress, key findings, new mathematical results and their impact on biology, any grant applications made as a consequence of the project, and future directions. This report must also provide information (level of support and research tasks) about any trainees supported by the funds for the NITMB evaluation process.
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Any software, datasets, or models resulting from supported research must be made publically available, well-documented, and easily accessible when published as preprint or paper; such materials will be posted on the NITMB web page, Github, Datajoint, Dryad, etc.
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Each team must also produce a publicly accessible blog, social media post and/or video abstract for each publication resulting from the proposed research. The above artifacts will be evaluated during the competitive renewal process if sought.
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The principal investigators are required to present their project research at an NITMB convening activity (e.g., a workshop or conference).
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All papers and conference presentations resulting from the funded work are expected to acknowledge the NITMB award, as detailed at https://www.nitmb.org/acknowledgements.
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Internal Research Project funds can only be used at Northwestern and UChicago. However, external collaborators may apply to the Visiting Scholars Program to facilitate engagement with internal research projects. Short-term (less than 10 days) and long-term (10 days or more) visits are available.
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If the project involves experiments on animals, all NSF protocols must be followed and appropriate forms must be submitted to the NITMB.
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Procedures
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Timeline: ​
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Application deadline 04/15/25
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Evaluation complete 05/15/25
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Work start date 09/1/25
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Submission should include a
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Submission should include a
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4-page research proposal. The proposal should address all the merit review criteria described above and list the names of the personnel to be supported (if known at the time of application).
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A budget with justification using a provided template. If supplies are requested, please include a short itemized budget in the justification. The budget must include clear labels for each line item indicating where expenses will be hosted: (NU) or (UC) for Northwestern and UChicago respectively. If a line item’s costs are shared between both institutions, they should be broken apart into multiple line items with individual costs to reflect the split.
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Biosketches in the NIH or NSF format for all investigators and collaborators.
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Pre-screening of applications will occur to ensure that they are complete and conform to eligibility requirements. Please respond promptly to any requests for document updates so that all proposals may be reviewed in a timely manner.
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Each application will be reviewed by two NITMB theme leaders. A common rubric/scoring system will be used for all applications. The committee will meet to debate and rank the applications based on the merit criteria. Our evaluation criteria will be grounded in the principles outlined at https://seedfund.nsf.gov/resources/review/merit-review/, without the focus on commercial impact.
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The committee recommends projects to be funded to the Deputy Director for Research. Once approved, the awarded applicants will be notified. The applicants who were not awarded funds will receive a one-page summary of their review and will be encouraged to apply as part of a subsequent call for proposals.
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Funding recipients must otherwise contribute to NITMB training and/or programming efforts, as described under Merit Review Criteria.
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Any changes in the project budget must be requested by the principal investigators for approval by the NITMB before changes are made.
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Background
Northwestern University and the University of Chicago have been awarded funds from the National Science Foundation and the Simons Foundation to establish the National Institute for Theory and Mathematics in Biology, or NITMB, based in downtown Chicago. The institute is the first of its kind in the U.S.
Together, the two universities are creating a nationwide collaborative research community that will generate new mathematical results and uncover the “rules of life” through theories, mathematical models, and computational and statistical tools. Foundational advances in biology and mathematics at the NITMB will have broad impacts, such as increased knowledge of human intelligence, advances in the biomedical sciences, and a better understanding of the effects of climate change on plants and animals. The institute offers bidirectional opportunities: Discoveries in biology will also motivate new developments in mathematics.
Critical goals for the NITMB are to catalyze the growth of mathematical biology in the U.S. and to become a national nexus for mathematical biology. NITMB has several mechanisms being used to achieve these goals, including internal (to Northwestern and UChicago) research projects. Important criteria for project funding are: (1) collaborative research bringing together people from different disciplines or subdisciplines; (2) ensuring the breadth of the NITMB research portfolio in both biology and mathematics; (3) encouraging creative, bold, high-risk high-reward research; and (4) supporting the development of new mathematics.
Proposals
Proposals may be submitted for funds for 12 months of support of at most
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2.0 FTE graduate research assistants OR 1.0 FTE graduate research assistant plus 1.0 FTE postdoc, and
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$10,000 direct costs for materials and supplies
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$5,000 direct costs for travel
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The research proposal must include the following:
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A statement defining the problem or phenomenon (mathematical or biological) that the research will address.
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A description of how the research will advance understanding of the biological phenomenon.
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A description of how the research will advance the development of new mathematics.
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A statement of which NITMB research themes are touched upon by the proposed research and why.
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A detailed description of the approaches that will be taken, methods used, anticipated outcomes, and contingency plans for all thrusts of the proposed research.
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A description of the participants in the research and how they will work together to achieve the project goals.
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A mentoring plan for trainees.
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A description of how investigators will engage with the NITMB.
Proposals should be submitted online at https://uchicago.infoready4.com/#competitionDetail/1963112 by April 15, 2025, at 11:59pm. Proposals should directly address the Merit Review Criteria and conform to the funding policies detailed below.
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Merit Review Criteria:
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Alignment with the research mission of the NITMB, including generating new mathematics inspired by biology and new biological discoveries driven by the application of mathematics.
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The extent to which the research will develop new mathematics (including pure and applied math, algorithms, computation, and statistical methods). This must be clearly articulated in the proposal. Applying existing computational tools to a new dataset is, on its own, insufficient to qualify as new math. Illustrative examples of “new mathematics” include (but are not limited to):
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Novel use of some branch/type of math in the study of a phenomenon 
(e.g., applying topology to a problem previously only addressed with regression models)
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The first time a phenomenon is quantitatively addressed
 (e.g., establishing a metric for 2d shapes)
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New pure and applied mathematics addressing theoretical holes
 (e.g., relaxing simplifying assumptions)
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The extent to which the research will have a high reward or impact even if it is high risk.
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The extent to which the project will broaden the portfolio of NITMB-supported research.
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How well the research integrates mathematics with biology, with investigators providing complementary expertise.
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Collaborations between mathematicians and experimentalists are encouraged, but projects are not required to have an experimental component and may use pre-existing datasets.
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The quality of the mentoring plan for trainees. Trainees funded through NITMB will be expected to participate in professional development activities, workshops, and present at work-in-progress meetings, annual retreats, and conferences.
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Collaborations between researchers at Northwestern University and the University of Chicago are preferred (though not required).
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Specific, Measurable, Achievable, Relevant, and Time-Bound (SMART) goals for team engagement with NITMB activities outside the funded research. Examples might include:
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Contributing to synergies and interactions among NITMB research projects
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Organizing a workshop
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Mentoring summer undergraduate research
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Serving on NITMB committees (e.g., postdoctoral fellow search, external grant proposal review and selection)
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Running a training activity or collection of tutorials
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Helping to organize meetings with the External Advisory Board and Scientific Advisory Board
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Substantive engagement with teaching-intensive institutions (TII) or Primary Undergraduate Institutions (PUI) partnering with NITMB
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Helping to organize and actively engaging with the NITMB Seminar Series and Work-in-Progress meetings.
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